nūhou

Ma muli o ka iwi iwi aza-BODIPY, hoʻokomo ʻo NIR1001 i nā pūʻulu hāʻawi electron (e laʻa, 4-N,N-diphenylaminophenyl) ma nā kūlana 2,6, e hana ana i kahi hoʻolālā D-π-D symmetric1. Hoʻopili kēia hoʻolālā i ka ʻāpana HOMO-LUMO, hoʻololi i ka piko absorption ma mua o 1000 nm a hoʻonui i ka hoʻoili kālā intramolecular (ICT). Ma THF, hōʻike ʻo NIR1001 i ʻelua-photon absorption (TPA) cross-section o 37 GM, kahi hoʻomaikaʻi ʻelua ʻelua ma mua o nā derivatives BODIPY kuʻuna. ʻO kona ola hauʻoli ʻo 1.2 ps e hiki ai i nā hoʻololi non-radiative kūpono, kūpono ia no ka photodynamic therapy (PDT).

Hōʻike nā helu DFT e kū mai ana ka mīkini hoʻoili kālā o NIR1001 mai ka wehe ʻana o π-electron ma waena o nā mea hāʻawi a me nā ʻāpana ʻae. Hoʻonui hou ka hoʻololi ʻana i ka methoxy i ka absorption NIR i ka puka aniani phototherapeutic (650-900 nm), e hoʻomaikaʻi ana i ka sensitivity1. Ke hoʻohālikelike ʻia me nā dyes AF o ke Kulanui o Fudan, mālama ʻo NIR1001 i kahi paona molekala liʻiliʻi (<500 Da) me 40% kiʻekiʻe photostability. ʻO ka hoʻololi ʻana i ka carboxylation e hoʻomaikaʻi i ka solubility wai (cLogD=1.2), e hōʻemi ana i ka adsorption non-specific i nā ʻōnaehana biological

3. Nā noi lāʻau lapaʻau
I ka bioimaging, hiki i ka hCG-conjugated probe hCG-NIR1001 ke kiʻi kiʻi kiʻekiʻe o nā follicles ovarian a me nā micro-metastases ma lalo o 808 nm excitation. Me ka hohonu komo o 3 knm ma NIR-II, ʻoi aku ia ma mua o ka NIR-I probes ma ʻekolu manawa, ʻoiai e hōʻemi ana i ka fluorescence hope e 60%. I loko o kahi hoʻohālike hōʻeha ʻāʻī ʻiole, hōʻike ʻo NIR1001 i ka 85% renal-specific uptake, e ʻike ana i ka pōʻino ʻeono manawa ʻoi aku ka wikiwiki ma mua o nā mana macromolecular.
No PDT, NIR1001 hoʻopuka i nā ʻano oxygen reactive (ROS) ma 0.85 μmol/J ma lalo o 1064 nm laser irradiation, hoʻoulu pono i ka apoptosis cell tumor. ʻO ka liposome-encapsulated NIR1001 nanoparticles (NPs) e hōʻiliʻili i nā manawa 7.2 i loko o nā maʻi maʻi ma mua o ke kala manuahi, e hōʻemi ana i nā hopena i waho.
4. Ka nānā 'ana i ka 'oihana a me ke kaiapuni
Ma nā noi ʻoihana, ua hoʻohui ʻia ʻo NIR1001 i loko o Juhang Technology's SupNIR-1000 anana no ka ʻohi ʻana i nā huaʻai, loiloi maikaʻi o ka ʻiʻo, a me ka hana paka. Ke hana nei ma ka laulā 900-1700 nm, e ana like ia i ka ʻike kōpaʻa, ka makū, a me nā koena pesticide i loko o 30 kekona me ± (50ppm+5% heluhelu) pololei. I loko o ka automotive CO2 sensors (ACDS-1001), NIR1001 hiki i ka manawa maoli me ka T90≤25s pane manawa a me ka 15 makahiki ola.
No ka ʻike ʻana i ke kaiapuni, ʻike ʻo NIR1001-functionalized probes i nā metala kaumaha i ka wai. I loko o ka pH 6.5-8.0, hoʻopili ʻia ka ikaika o ka fluorescence me ka Hg²⁺ ka nui (0.1-10 μM) me ka palena ʻike o 0.05 μM, ʻoi aku ka maikaʻi o nā ʻano colorimetric e ʻelua kauoha o ka nui.
5. ʻO ka ʻenehana hou a me ke kālepa ʻana
Qingdao Topwell Materialshoʻohana i ka synthesis mau e hana i ka NIR1001 ma 99.5% maʻemaʻe, me ka mana 50 kg / batch. Ke hoʻohana nei i nā reactors microchannel, hoʻemi ʻia ka manawa condensation Knoevenagel mai 12 mau hola a 30 mau minuke, e ʻoki ana i ka hoʻohana ʻana i ka ikehu e 60%. ʻO ka ISO 13485-certified NIR1001 series e hoʻomalu i ka mākeke biomedical.